Retired FBI Special Agent Joel Campbell (James Spader) lives in Chicago, where he is struggling to come to terms with his failure to capture a serial killer back when he was working in Los Angeles. Campbell attends therapy sessions with Dr. Polly Beilman (Marisa Tomei), but otherwise has no other friends or social life.

Campbell learns that a girl who lived in his apartment building has been killed. He does not pay it much attention until he opens his mail and finds that a picture of the girl had been sent to his apartment three days before the murder. He brings this information to the attention of the detective on the case, Det. Mackie (Chris Ellis), and comes to the conclusion that the same serial killer has arrived in Chicago. FBI Special Agent in Charge Ibby (Ernie Hudson) tries to persuade Campbell to return to the case, but he refuses.

One night Campbell receives a phone call from David Griffin (Keanu Reeves), the serial killer, who reveals that he followed Campbell to Chicago and wants to rebuild the "rapport" they once had. Griffin tells Campbell that he will send a photo of a girl in the morning, and Campbell has until 9:00 pm that night to find her. Campbell tells Ibby that he wants back in on the case, and his request is granted.
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