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In AD 2154,humans are engaged in harvesting the resources of Pandora, the lush moon of Polyphemus, one of three gas giants that orbit Alpha Centauri A, 4.3 light years from Earth. Pandora is filled with incredible life forms, and is home to the Na’vi, an indigenous sentient humanoid race who are considered primitive by human standards. The Na'vi are tailed, slender creatures with sparkling blue skin, standing three meters tall. They live in harmony with their unspoiled world, which the humans have found to be rich with unobtainium, a valuable mineral.

Humans are unable to breathe the Pandoran atmosphere; in order to interact with the Na'vi, human scientists have created genetically engineered human-Na'vi hybrid bodies called Avatars, and use them to interact with the natives and gain their trust for a relocating operation. A human who shares genetic material with the avatar can be mentally linked to it, allowing them to control its functions and experience what it experiences, while their own body sleeps. The story's protagonist, Jake Sully (Sam Worthington), is a former U.S. Marine who was wounded and paralyzed from the waist down in combat on Earth. His twin brother Tony was a scientist working on the Avatar program; when he is killed, Jake is extended the opportunity to take his brother's place, as he shares Tony's genetic material and is therefore compatible with his avatar.
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